Fig. 6

A Average expression of CCL4 in each sample in control and treated CD8 T cells with MAST DE adjusted p. B Cohen’s effect size and p of t-test comparison of cytotoxic effector pathway activity between control and treated CD8 T cells from each individual sample. C Expression of respective genes in cells from TR or TNR baseline T0 samples with Seurat Wilcoxon adjusted p. D Proportions of CD8 T cell subtypes in baselineT0 samples corresponding to transcriptional responders (TR) or non-responders (TNR). E Expression of gene signature of CD8 T cell dysfunction in TR and TNR with t-test p. F Cytotoxic effector pathway activity in control and treated cytotoxic and dysfunctional CD8 T cells with t-test p. G Schematic representation summarizing the ex vivo effects of GITR agonist in the TME