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Fig. 2 | Genome Medicine

Fig. 2

From: Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of β-cell function and insulin sensitivity in Africans without type 2 diabetes

Fig. 2

Heat map of A associations, B univariable MR causal associations, and C multivariable MR causal associations. The colour gradient reflects negative (red) and positive (blue) Z values for T2D and T values for the HOMA measures. HOMA analyses were performed in non-T2D individuals only. For T2D in panels B and C, the estimates from the inverse variance weighted (IVW) random effects model are shown. An asterisk indicates statistical significance at a Bonferroni-corrected P-value of < 0.0045 (= 0.05/11 cytokines and hormones)

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Genome Medicine

ISSN: 1756-994X

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