Skip to main content

Table 2 Novel SNPs association with ischemic stroke*

From: Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans

Chr.

Position hg38

rsID

Gene(s)

Ref Allele

Alt Allele

HWE P-value

MAF

Model 0# P-value

Model 1 P-value

Model 2 P-value

Model 3 P-value

Model 4 P-value

Model 5 P-value

3

151678293

rs6440776

MIR5186-AADACL2

C

T

0.13

0.37

1.93E−07

3.71E−08

3.81E−08

5.59E−08

1.11E−07

2.02E−07

5

8496166

rs57085808

MIR4458HG−LINC02199

G

C

0.37

0.12

1.49E−06

2.70E−07

3.22E−07

3.13E−07

1.22E−06

6.40E−07

  1. *Only SNPs were included in the table if SNP has at least 5 SNPs in linkage disequilibrium (LD) within the genomic region and at least 3 of the models had P-value < 10−6
  2. #Model 0: stroke status ~ sex + age + PCs1 … 10 + SNP; model 1: stroke status ~ sex + age + PCs1 … 10 + SNP + hypertension; model 2: stroke status ~ sex + age + PCs1 … 10 + SNP + hypertension + diabetes; model 3: stroke status ~ sex + age + PCs1 … 10 + SNP + hypertension + diabetes + dyslipidemia; model 4: stroke status ~ sex + age + PCs1 … 10 + SNP + hypertension + diabetes + dyslipidemia + cardiac disease status; model 5: stroke status ~ sex + age + PCs1 … 10 + SNP + hypertension + diabetes + dyslipidemia + cardiac disease status + waist-hip ratio