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Table 4 Results from MANTRA using SIREN, COMPASS, and MEGASTROKE studies with Log10 (Bayes factor)≥10

From: Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans

Chr.

Pos (Hg38)

rsSNP

Gene(s) hg38

Gene regions hg38

Ref/Alt

log10 Bayes factor

Posterior probability

Total samples

SIREN P-value

COMPASS P-value

MEGASTROKE P-value

Effect size dir*

4

110755885

rs2634074

PITX2-MIR297

Intergenic

A/T

11.32

0.463

471334

0.797

0.383

5.91E−15

+−−

110764459

rs2466455

PITX2-MIR297

Intergenic

C/T

11.36

0.478

472086

0.920

0.445

8.87E−15

−++

110767596

rs2723334

PITX2-MIR297

Intergenic

C/T

10.89

0.629

472166

0.800

0.511

1.49E−14

+−−

110775495

rs6847935

PITX2-MIR297

Intergenic

T/A

11.20

0.826

470846

0.093

0.288

1.80E−14

−++

110776412

rs1906616

PITX2-MIR297

Intergenic

G/A

10.45

0.83

472040

0.118

0.311

3.98E−14

−++

110776952

rs6837901

PITX2-MIR297

Intergenic

C/T

11.02

0.828

472049

0.118

0.342

1.54E−14

−++

110778529

rs67249485

PITX2-MIR297

Intergenic

T/A

10.93

0.824

472063

0.118

0.299

1.65E−14

−++

110778675

rs6820568

PITX2-MIR297

Intergenic

T/C

10.93

0.811

472056

0.143

0.378

1.83E−14

−++

110780642

rs1906615

PITX2-MIR297

Intergenic

T/G

10.57

0.635

472077

0.320

0.375

4.41E−14

−++

110782924

rs2129983

PITX2-MIR297

Intergenic

G/A

11.28

0.305

471995

0.797

0.176

2.36E−14

−++

110782987

rs2129982

PITX2-MIR297

Intergenic

G/A

10.78

0.867

472167

0.073

0.287

5.86E−14

−++

110783380

rs6854111

PITX2-MIR297

Intergenic

T/A

11.12

0.573

471394

0.246

0.214

1.99E−14

−++

110784139

rs12639654

PITX2-MIR297

Intergenic

T/C

10.02

0.129

469158

0.760

0.400

2.01E−12

−++

110791276

rs2129977

PITX2-MIR297

Intergenic

A/G

11.40

0.398

472105

0.393

0.136

2.65E−14

−++

110796911

rs6843082

PITX2-MIR297

Intergenic

G/A

10.28

0.261

471736

0.573

0.122

6.73E−13

−++

7

19009765

rs2107595

HDAC9-TWIST1

Intergenic

A/G

10.40

0.072

472122

0.137

0.053

2.33E−11

+++

12

111395984

rs10774624

FAM109A-SH2B3

Intergenic

G/A

11.93

0.139

469904

0.430

0.224

7.66E−14

−++

111466567

rs4766578

ATXN2

Intronic

T/A

10.81

0.143

469940

0.423

0.185

1.36E−12

−++

111494996

rs7137828

ATXN2

Intronic

C/T

11.00

0.141

469942

0.422

0.173

6.61E−13

−++

111569952

rs653178

ATXN2

Intronic

C/T

11.58

0.141

469939

0.410

0.228

1.59E−13

−++

111634620

rs11065987

ATXN2-AS-BRAP

Intergenic

G/A

10.12

0.152

469938

0.467

0.747

5.81E−13

−++

112049014

rs17696736

NAA25

Intronic

G/A

10.32

0.176

469948

0.498

0.518

2.16E−12

−++

  1. *Effect size direction order: SIREN, COMPASS, and MEGASTROKE; We used the baseline model from SIREN for MANTRA analysis: Stroke Status ~ Sex + Age + PCs1…10 + SNP
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