Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans

Table 5 SIREN study driven MANTRA results with Log₁₀ (Bayes factor)≥4.0^*

Chr.	Position (hg38)	rsID	Gene(s) hg38	Gene region hg38	Ref/Alt	Log₁₀ Bayes factor	Posterior probability	Total samples	SIREN P-value	COMPASS P-value	MEGASTROKE P-value	Effect size dir^#
3	151678293	rs6440776	MIR5186-AADACL2	Intergenic	T/C	5.102	1	472150	1.94E−07	0.873	0.468	−−−
3	151681716	rs2410883	MIR5186-AADACL2	Intergenic	G/A	5.039	1	472150	2.46E−07	0.688	0.493	−−−
7	53526642	rs2194650	POM121L12-LINC01446	Intergenic	T/C	4.398	1	472156	2.52E−07	0.292	0.604	++−
7	53527922	rs4541851	POM121L12-LINC01446	Intergenic	G/A	4.733	1	472156	2.89E−07	0.308	0.493	++−
7	53532401	rs10230418	POM121L12-LINC01446	Intergenic	G/A	4.393	1	472144	3.38E−07	0.279	0.630	++−
7	53520258	rs10250977	POM121L12-LINC01446	Intergenic	T/C	4.456	1	472162	3.42E−07	0.297	0.626	++−
7	53515752	rs11238270	POM121L12-LINC01446	Intergenic	C/T	4.270	1	472162	3.73E−07	0.272	0.639	++−
7	53516754	rs4947814	POM121L12-LINC01446	Intergenic	C/A	4.255	1	472163	4.08E−07	0.164	0.718	++−
7	53534088	rs1559587	POM121L12-LINC01446	Intergenic	A/T	4.452	1	472156	5.35E−07	0.286	0.619	++−
18	75791508	rs7239115	LINC01898-LOC339298	Intergenic	C/T	5.780	1	472023	1.10E−06	0.126	0.008	−++
18	75787931	rs898487	LINC01898-LOC339298	Intergenic	G/A	4.594	1	472143	2.06E−06	0.128	0.108	−++
18	75788278	rs7228334	LINC01898-LOC339298	Intergenic	C/T	5.491	1	472131	2.50E−06	0.128	0.012	−++
20	19535610	rs6035372	SLC24A3	Intronic	G/A	4.253	1	472167	2.28E−05	0.102	0.046	+−−

*Mantra results with Bayes Factor ≥ 4 for significant loci in SIREN with P-value<1.0E-04
^#Effect size direction order: SIREN, COMPASS, and MEGASTROKE; We used the baseline model from SIREN for MANTRA analysis: Stroke Status ~ Sex + Age + PCs1…10 + SNP

ISSN: 1756-994X