Table 1 Sensitivity and specificity of AMR prediction for selected antibiotics and their respective antibiotic resistance encoding genes (ARG). The number of resistant and sensitive phenotypes given are based on the antibiograms (n = 451, EUCAST). “*” indicates sample size of 1
Antibiotic | Genes | Resistant phenotypes | Sensitive phenotypes | Sensitivity [%] | Specificity [%] |
|---|---|---|---|---|---|
Penicillin | blaZ | 450 | 1 | 95.8 | 0* |
Oxacillin | mecA | 451 | 0 | 99.1 | - |
Clindamycin | ermA, ermC | 440 | 11 | 98.4 | 27.3 |
Erythromycin | ermA, ermC | 444 | 7 | 98.4 | 42.9 |
Gentamicin | aac(6)-aph(2′) | 55 | 396 | 89.1 | 98.2 |
Tetracycline | tetM, tetK | 450 | 1 | 100.0 | 100 |
Ciprofloxacin | gyrA, grlA | 1 | 450 | 0.0* | 98 |