Fig. 5
From: Biological basis of extensive pleiotropy between blood traits and cancer risk
High frequency of pleiotropic variants in RNY-containing loci. a Histogram showing the relative contribution of pleiotropic variants (%; Y-axis) in RNY-containing loci (± 50 kb centered on each variant) across cancer studies (X-axis). b Genomic distribution of pleiotropic variants in RNY-containing loci (red dots) and all RNY-containing loci (horizontal bars) from chromosome (chr) 1 to 22. c Graph showing the percentage of variants (SNPs) mapped to RNYs (± 50 kb) in 1000 random sets of 8155 SNPs (European MAF > 0.01 and r2 < 0.8) and the observed percentage in the blood trait–cancer pleiotropy set (6.6%; 270/4,093). d Histogram showing the distribution of identified RNA repeat elements across the pleiotropic loci (4093 variants; ± 50 kb). The families of repeat elements are indicated (X-axis). e Graph showing the percentage of variants (SNPs) mapped to RNYs (± 50 kb) in 1000 random sets of 3847 SNPs (no filter criteria) and the observed percentage in the GWAS catalog of cancer risk variants (3.7%; 144/3,845)