Fig. 7

Pleiotropic RNYs are linked to SLE risk and plasma RNYs are relatively abundant preceding breast cancer diagnosis. a Scatter plot of the correlation of the levels of expression between RO60 and the pleiotropic or non-pleiotropic RNY signatures in TCGA normal tissue. The PCCs and p values are indicated. b Graphs showing the number of variants (SNPs) identified as pleiotropic in RNYs (± 50 kb) and correlated (European r² > 0.4, left panel; r² > 0.8, right panel) with SLE GWAS catalog variants, and compared with the results of equivalent 1000 random variant sets (European MAF > 0.01). c Box plot showing overexpression of the pleiotropic RNY signature in plasma of women who developed sporadic breast cancer (< 12 months after blood test) relative to matched controls who did not develop any neoplasm. The significance (p) of the Wilcoxon rank test is shown. d Box plot showing overexpression of the pleiotropic RNY signature in plasma of women carriers of pathological variants of BRCA1 and BRCA2 who developed breast cancer (< 12 months after blood test) relative to matched controls who did not develop any neoplasm. The significance (p) of the Wilcoxon rank test is shown