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Fig. 2 | Genome Medicine

Fig. 2

From: Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features

Fig. 2

Oncoplot summary of SNVs and CNAs affecting known prostate cancer diver genes (Intogen) in the sequenced samples. Samples are grouped by patient ID and annotated for sample site. Integer copy numbers < 2 and > 2 were classified as deletion (Del) and amplification (Amp), respectively. Proportions of the six possible types of mutational conversions in the SNVs are shown at the bottom. Copy number alterations that were not called by Battenberg, but inferred by parsimony and supporting evidence from raw data are shown as unfilled shapes. Mutation type legend applies both to the oncoplot (middle panel) and the TMB plot (top panel) (TMB, total mutation burden; in this figure, refer to SNVs in coding regions)

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Genome Medicine

ISSN: 1756-994X

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