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Fig. 3 | Genome Medicine

Fig. 3

From: Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features

Fig. 3

A Phylogenetic trees and clone maps of patient #02, B patient #08, and C patient #13, showing diverse routes of tumour evolution within the prostate, local invasion to seminal vesicles, and metastasis to lymph nodes. The phylogenetic trees are annotated with SNVs and CNAs involving known prostate cancer driver genes (Intogen). The numbers on the edges of the phylogenetic tree and the X-axis scale represent the number of SNVs assigned to the daughter clone. Metastatic events to lymph nodes are annotated on the phylogenetic tree with dashed arrows. Clone names are sorted based on cluster size, i.e. A > B > C and so on

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Genome Medicine

ISSN: 1756-994X

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