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Fig. 4 | Genome Medicine

Fig. 4

From: Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features

Fig. 4

A Amphicrine morphology in lymph nodes, as seen by H&E staining, immunohistochemistry for Synaptophysin and CD56. B Phylogenetic tree for patient #10, with several copy number changes at the branching points. Clones that were likely sources of metastatic seeding are connected to the lymph node sample IDs by dashed arrows. C Clone map showing inferred route of cancer progression; clone J in the RLat punch expands in 17E_Ne and is associated with transformation from adenocarcinoma to amphicrine appearance

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Genome Medicine

ISSN: 1756-994X

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