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Fig. 5 | Genome Medicine

Fig. 5

From: Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features

Fig. 5

A Phylogenetic tree for #15 showing clones I, G and C as potential sources of metastatic seeding to lymph nodes. B Clone map of patient #15 showing routes of intra-prostatic spread and metastasis to lymph nodes. Clone H (pink) expands to become clonal in LPZMid. C A H&E section adjacent to the sequenced samples with areas corresponding to LPZMid and LPZLat on a plane close to the punches (superscripted with adj to denote this) showing different morphologies with D matching PSMA expression and E numbers of tumour-infiltrating lymphocyte counted by image analysis in corresponding regions compared to a distant non-tumour region

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Genome Medicine

ISSN: 1756-994X

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