Fig. 6

Prioritize risk genes in CellNetdb. A Prioritize risk genes using the interactome network specific to malignant melanocytes in uveal melanoma. The bar plot depicts the stationary probability for each top-ranked gene from random walk with restart. The reported cancer driver genes in the NCG 6.0 database are labeled in red. B Prioritize risk genes using the interactome network specific to malignant myeloid cells in acute myeloid leukemia. The reported cancer driver genes in the NCG 6.0 database are labeled in red. C Prioritize risk genes using the interactome networks specific to exhausted T cells in the pan-tumor TIMEs. D–F The expression levels of KLRD1 (D), CD27 (E), and LGALS9 (F) in six ICB therapy cohorts. The boxplots show the difference of their expression levels between ICB therapy response and non-response groups. The cohorts of different tumor types are labeled, including skin cutaneous melanoma (SKCM), clear cell renal cell carcinoma (ccRCC), and non-small cell lung carcinoma (NSCLC). The asterisks represent the degree of significance calculated using Limma (* P-value < 0.05, ** P-value < 0.01, *** P-value < 0.001). G–I The Kaplan–Meier curves of overall survival (OS) and progression-free survival (PFS) depict the differences between patients’ groups stratified by the expression level of KLRD1 (G), CD27 (H), and LGALS9 (I), respectively