Table 2 Distribution of P/LP variants per Qatar subpopulation
From: Burden of Mendelian disorders in a large Middle Eastern biobank
Subpopulation | Carriers of P/LP variants (%) | Average P/LP variants per subject (range) | Homozygotes of P/LP variants for recessive conditions (%) | Fold enrichment of homozygote P/LP relative to ADM | Heterozygotes of P/LP variants in dominant conditions (%) | Fold enrichment of heterozygote P/LP relative to ADM |
|---|---|---|---|---|---|---|
QGP-PAR | 794 (75) | 1.4 (0–6) | 25 (3.15) | 5.8a | 22 (2.8) | 0.4 |
QGP-GAR | 1507 (65) | 1.1 (0–7) | 10 (0.66) | 1.2 | 71 (4.7) | 0.6 |
QGP-ADM | 739 (63) | 1.0 (0–6) | 4 (0.54) | 1 | 55 (7.4) | 1 |
QGP-AFR | 60 (65) | 1.0 (0–7) | 0 (0) | 0 | 8 (13.3) | 1.8 |
QGP-SAS | 19 (50) | 0.7 (0–3) | 0 (0) | 0 | 1 (5.3) | 0.7 |
QGP-WEP | 747 (54) | 0.8 (0–5) | 1 (0.13) | 0.2 | 76 (10.1) | 1.4 |