Fig. 4
Box plots of examples of differentially expressed metabolites in the primary and secondary bile acid synthesis metabolisms. Left panel: primary bile acids: glycocholate and taurocholate are increased in individuals with T2D compared to those without T2D. Middle panel: top diagram represents the primary and secondary bile acid synthesis pathway in the liver and the digestive lumen; the bottom represents the box plot of deoxycholate concentrations in individuals with T2D and without T2D. Right panel: Secondary bile acids, taurodeoxycholate and glycodeoxycholate are increased in individuals with T2D compared to those without T2D