Fig. 6

Analysis of biomarker panels for T2D based on ROC curve analyses. A ROC curve for the 10-metabolite biomarker panel in the discovery cohort. B Box plot of the predictive accuracy of the 10-metabolite biomarker panel in the discovery cohort. C Plot of the most important features of the 10-metabolite biomarker panel; 0 = non-T2D (individuals without T2D), 1 = T2D (individuals with T2D). D ROC curve for the 7-metabolite biomarker panel in the discovery cohort (panel restricted to non-established biomarkers). E ROC curve representing the replication of the identified biomarker panel in a different set of participants (replication cohort). F ROC curve representing the evaluation of the panel restricted to the non-established biomarkers in a different set of participants (replication cohort)