NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy

Table 3 Frequency calculation of patients with a NODAL variant by CHD lesion within laterality cohort (321 probands, Group 1a)

Lesion	Total	Total w/ *NODAL* variant	% with *NODAL* variant
Simple DTGA	49	3	6.1%
DORV with malposed GA	26	0 (2 in Mohapatra paper[13]	0.0%
CCTGA	26	4	15.4%
DILV, All	33	4	12.2%
DILV, D-looped	11	1	9.1%
DILV, L-looped	22	3	13.6%
Any L-looping	66	9	13.6%
Heterotaxy—Situs inversus with CHD	15	1	6.7%
Heterotaxy—Right atrial isomerism/Asplenia syndrome	68	7	10.3%

Table only reports cases within Group 1a, which was a consecutively recruited cohort of subjects with laterality congenital heart disease
CCTGA Congenitally corrected transposition of the great arteries, CHD Congenital heart disease, DILV Double inlet left ventricle, DORV Double outlet right ventricle, DTGA D-Transposition of the great arteries

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