Fig. 5

Classical CF phenotypes enriched in participants with >1 clinically relevant CFTR variant. A) Enriched phenotypes observed in patients with two CF-causing variants. B) Enriched phenotypes observed in patients with one CF-causing and a high impact variant. The top 10 enriched phenotypes are represented in bar graphs. The negative logarithm of the Bonferroni adjusted p-value was used to deduce the enrichment scores shown in the bars. Enrichment score >1.3 corresponds to a significance threshold of p<0.05