Table 1 Instrumental variable regression analysis and motif analysis to determine the deterministic genes of the DNA methylation signatures
| Â | Instrumental variable | Motif | ||
|---|---|---|---|---|
| Â | Missense | Frame shift | TSS | Gene body |
Hyper-MS1 | Â | Â | ZNF652(HepG2) | Â |
Hyper-MS2 | Â | CDH1 | TEAD1(HepG2) MafF(HepG2) LXH9(HCT116) HINFP(K562) TEAD3(HepG2) | Six4(MCF7) |
Hyper-MS3 | Â | Â | ZNF652(HepG2) | Â |
Hypo-MS1 | KEAP1 | Â | Jun-AP1(K562) Atf3(GBM) Fra1(BT549) NRF2(HepG2) | Jun-AP1(K562) Fra1(BT549) Atf3(GBM) NF-E2(K562) Bach1(K562) NRF2(HepG2) RUNX2(PCa) EIk1(Hela) ELF5(T47D) |
Hypo-MS2 | AKAP1 C16orf2 | FOXA1 | NFIL3(HepG2) Atf1(K562) | Jun-AP1(K562) Fra1(BT549) Atf3(GBM) NF-E2(K562) AR-halfsite(LNCAP) |
Hypo-MS3 | Â | Â | PSE(K562) RUNX2(PCa) Jun-AP1(K562) Fra1(BT549) Atf3(GBM) NF-E2(K562) RARa(K562) | Jun-AP1(K562) Fra1(BT549) Atf3(GBM) Bach1(K562) NF-E2(K562) c-Myc(LNCAP) Err \(\alpha\)(HepG2) bHLHE40(HepG2) Max(K562) |
Hypo-MS4 | TP53 | TP53 FOXA1 | COUP-TFII(K562) | Forkhead (Panc1) HRE(HepG2) |
Hypo-MS5 | AKAP9 | Â | Â | HNF4a(HepG2) |
Hypo-MS6 | INHBE | BAP1 | Bach1(K562) | Â |
Hypo-MS7 | Â | BAP1 BMPR2 | AP-2alpha (Hela) Fra1(BT549) RUNX2(PCa) | Atf3(GBM) Fra1(BT549) Jun-AP1(K562) |