Fig. 6

HIV infection-associated gut bacteria, proteins and metabolites and prevalent diabetes in WIHS women (N = 426). Data were associations and 95% confidence intervals of selected gut bacteria genera (A), proteins (B), and metabolites (C) with HIV infection (i.e., positive serostatus) and prevalent diabetes. Associations were derived via multivariable logistic regression models adjusting for age at visit, study site, race/ethnicity, annual household income, education, smoking, alcohol consumption, fasting status, antibiotics use (for gut bacterial features), and HIV serostatus (for association with prevalent diabetes). Only omics features significantly associated HIV infection at FDR-q < 0.1 were included here. Detailed numeric results were shown in Table S9. Detailed numeric results and feature annotations were shown in Table S9. CD8A: T-cell surface glycoprotein CD8 alpha chain, CXCL9: C-X-C motif chemokine 9, CXCL10: C-X-C motif chemokine 10, CCL25: C–C motif chemokine 25, SLAMF1: signaling lymphocytic activation molecule, TNF: tumor necrosis factor, CD244: natural killer cell receptor 2B4, TNFRSF9: tumor necrosis factor receptor superfamily member 9, IL-12B: interleukin-12 subunit beta, IL-15RA: interleukin-15 receptor subunit alpha, CXCL11: C-X-C motif chemokine 11, IL18: interleukin-18 (IL-18), MCP-1: monocyte chemotactic protein 1, ADA: adenosine deaminase, EN-RAGE: protein S100-A12, LAP TGF-β-1: latency-associated peptide transforming growth factor beta-1, DNER: delta and Notch-like epidermal growth factor-related receptor, TGF-α : transforming growth factor alpha