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Table 1 Patient characteristics in the MGH primary care physician network with genetic data by scenario

From: Polygenic scores for longitudinal prediction of incident type 2 diabetes in an ancestrally and medically diverse primary care physician network: a patient cohort study

 

Scenario 1

Scenario 2

Scenario 3

Scenario 4

n

14,712

13,670

9867

7331

Age, mean (SD)

48.9 (15.7)

48.9 (15.4)

51.3 (14.6)

53.9 (13.2)

Female, n (%)

7965 (54.1%)

7430 (54.4%)

5124 (51.9%)

3480 (47.5%)

Current smokers, n (%)

902 (6.1%)

766 (5.2%)

554 (3.8%)

352 (2.4%)

Self-Reported Race

 White, n (%)

12,697 (86.3%)

11,814 (86.4%)

8592 (87.1%)

6511 (88.8%)

 Black/African American, n (%)

525 (3.6%)

492 (3.6%)

373 (3.8%)

267 (3.6%)

 Asian, n (%)

330 (2.2%)

293 (2.1%)

187 (1.9%)

119 (1.6%)

 Other/unknown, n (%)

1160 (7.9%)

1071 (7.8%)

715 (7.2%)

434 (5.9%)

Self-Reported Ethnicity

 Hispanic, n (%)

227 (1.5%)

185 (1.4%)

123 (1.2%)

80 (1.1%)

 Non-Hispanic, n (%)

12,407 (84.3%)

11,502 (84.1%)

8294 (84.1%)

6139 (83.7%)

 Other/unknown, n (%)

2078 (14.4%)

1983 (14.5%)

1450 (14.7%)

1112 (15.2%)

Genetic ancestry

 EUR, n (%)

12,508 (85.0%)

11,639 (85.1%)

8450 (85.6%)

6406 (87.4%)

 AFR, n (%)

520 (3.5%)

489 (3.6%)

377 (3.8%)

269 (3.7%)

 AMR, n (%)

1003 (6.8%)

924 (6.8%)

627 (6.4%)

357 (4.9%)

 ASIAN, n (%)

357 (2.4%)

316 (2.3%)

202 (2.0%)

134 (1.8%)

 Other, n (%)

324 (2,2%)

302 (2.2%)

211 (2.1%)

165 (2.3%)

Highest educational attainment

 High school, n (%)

3364 (22.9%)

3113 (22.8%)

2357 (23.9%)

1683 (23.0%)

 Undergraduate, n (%)

6378 (43.4%)

5956 (43.6%)

4134 (41.9%)

3045 (41.5%)

 Graduate, n (%)

2195 (14.9%)

2088 (15.3%)

1458 (14.8%)

1106 (15.1%)

 Other/unknown, n (%)

2775 (18.9%)

2513 (18.4%)

1918 (19.4%)

1497 (20.4%)

Diagnoses at baseline

 Coronary artery disease, n (%)

713 (4.8%)

627 (4.6%)

573 (5.8%)

531 (7.2%)

 Chronic kidney disease, n (%)

376 (2.6%)

321 (2.3%)

301 (3.1%)

264 (3.6%)

 Hypertension, n (%)

3247 (22.1%)

3046 (22.3%)

2793 (28.3%)

2410 (32.9%)

 Chronic heart failure, n (%)

207 (1.4%)

177 (1.3%)

162 (1.6%)

126 (1.7%)

 Peripheral vascular disease, n (%)

136 (0.9%)

115 (0.8%)

103 (1.0%)

78 (1.1%)

Family history of T2D, n (%)

581 (3.9%)

555 (4.1%)

413 (4.2%)

309 (4.2%)

Family history of CAD, n (%)

4319 (29.4%)

4109 (30.1%)

3018 (30.6%)

2330 (31.8%)

Incident diabetes during follow-up, n (%)

1908 (13.0%)

1800 (13.2%)

1487 (15.1%)

1265 (17.3%)

Max follow-up time (years)

15.9

15.9

15.9

15.9

BMI, mean (SD)

 

28.3 (5.7)

28.5 (5.7)

28.7 (5.6)

Systolic blood pressure, mean (SD)

 

125.7 (11.8)

126.6 (11.7)

127.6 (11.3)

Diastolic blood pressure, mean (SD)

 

75.0 (6.7)

74.9 (6.6)

74.9 (6.5)

Random glucose, mean (SD)

  

97.2 (22.9)

96.9 (22.0)

Total cholesterol, mean (SD)

   

189.9 (35.9)

HDL, mean (SD)

   

56.5 (17.1)

Triglyceride, mean (SD)

   

128.2 (86.6)

  1. Follow-up time was calculated as the length of time between the first diagnosis of diabetes and either January 1, 2000, or a patient’s first clinical encounter into the PCP. Data was left-censored to remove participants with a diagnosis of T2D before their start date. Only complete cases for all clinical risk factors included in each scenario were used in the primary analyses. Clinical risk factors at the time of first encounter in each scenario are as follows: scenario 1 age, sex; scenario 2 age, sex, BMI, family history of T2D, systolic blood pressure; scenario 3 age, sex, BMI, family history of T2D, systolic blood pressure, random glucose; scenario 4 age, sex, BMI, family history of T2D, systolic blood pressure, triglycerides, total cholesterol, and HDL combined into a clinical risk score and random glucose
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