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Table 1 HLA alleles associated with adverse drug reactions and cell availability in the HLA-typed archive

From: In silicoanalysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

      Number of carriers of HLA alleles associated with DILI in our cohort (n= 385)
Drug HLA allele Reaction (ethnicity) Odds ratio (95% CI) Reference Hmz Htz
Drug-induced hypersensitivity reactions       
   Abacavir B*57:01 Hypersensitivity (all) 117 (29-481) [14] 1 25
   Carbamazepine B*15:02 SJS/TEN (Han Chinese) 2,504 (126-49,522) [4] 1 6
  A*31:01 All phenotypes (Caucasian) 12.12 (4.03-20.65) [17] 0 23
   Allopurinol B*58:01 SJS (Han Chinese) 580.3 (34.4-9,780.9)   0 6
   SJS (Caucasian) 80 (34-187) [10, 12]   
   Nevirapine DRB1*01:01 Hypersensitivity (Caucasian) 4.8 (1.3-16.8) [16] 3 52
   Lamotrigine B*38 SJS/TEN (Caucasian) 6.8 (2.6-18) [12] 0 7
Drug-induced liver injury       
   Flucloxacillin B*57:01 DILI (Caucasian) 80.6 (22.8-284.9) [6] 1 25
   Ximelagatran DRB1*07:01 DILI (Caucasian) 4.4 (2.2-8.9) [11] 10 91
  DQA1*02:01   4.4 (2.2-8.1)   ND ND
   Lumiracoxib DRB1*15:01 DILI (Caucasian) 7.5 (5.0 to 11.3) [21] 10 100
  DQA1*01:02   6.3 (4.1 to 9.6)   ND ND
  DQB1*06:02   6.9 (4.6 to 10.3)   8 90
   Co-amoxiclav DRB1*15:01 and DILI (Caucasian) 2.8 (2.1 to 3.8) [7, 8, 13, 18] 10 100
  DQB1*06:02     8 90
  A*02:01   2.3 (1.8 to 2.9)   46 153
   Antituberculosis (isoniazid, rifampicin, pyrazinamide) DQB1*02:01 DILI (Indian) 1.9 (1.0 to 3.9) [20] 20 143
   Lapatinib DQA1*02:01 DILI (Caucasian) 2.2 (1.1 to 5.7) [22] ND ND
    9.0 (3.2 to 27.4)    
  DRB1*07:01   6.9 (2.5 to 19.9)   10 91
  DQB1*02:02   6.9 (2.5 to 19.6)   0 0
   Diclofenac DRB1*13 DILI (Caucasian) - [5] - -
   Clometacin B*08 DILI - [19] - -
   Ticlopidine A*33:03 DILI (Japanese) 13.0 (4.4 to 38.6) [9] 1 8
  1. Human leukocyte antigen (HLA) alleles associated with hypersensitivity reactions and drug-induced liver injury (DILI) are presented. All but two DILI studies (one Japanese and one Indian) were conducted in individuals of Caucasian ancestry. The number of individuals whose peripheral mononuclear cells are stored in the HLA-typed archive (n = 385) and who are carriers of HLA alleles implicated in these reactions is shown. CI, confidence Interval; Hmz, homozygotes; Htz, heterozygotes; ND, not determined (DQA1 locus not genotyped in ENW cohort); SJS, Stevens Johnson syndrome; TEN, toxic epidermal necrolysis.
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Genome Medicine

ISSN: 1756-994X

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