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Table 3 Allele and genotype frequencies in Caucasians from the HLA-typed archive described in the present study (North West England, n = 298)

From: In silicoanalysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

HLA-A HLA-B HLA-C HLA-DRB1 HLA-DQB1
Allele AF GF (%) Allele AF GF (%) Allele AF GF (%) Allele AF GF (%) Allele AF GF (%)
A*01:01g 0.208 38.6 B*07:02g 0.153 27.5 C*01:02g 0.040 8.1 DRB1*01:01:01 0.086 16.1 DQB1*02:01g 0.273 48.0
A*01:06 0.002 0.3 B*07:05g 0.003 0.7 C*02:02:02 0.035 7.0 DRB1*01:02:01 0.007 1.3 DQB1*03:01g 0.154 28.2
A*02:01g 0.289 50.7 B*08:01g 0.154 29.9 C*03:02 0.003 0.7 DRB1*01:03 0.018 3.7 DQB1*03:02:01 0.116 21.5
A*02:05g 0.010 2.0 B*13:02 0.007 1.3 C*03:03g 0.064 12.8 DRB1*03:01:01 0.154 28.9 DQB1*03:03:02 0.049 9.7
A*02:20:01 0.002 0.3 B*14:01 0.010 2.0 C*03:04 0.076 14.4 DRB1*04:01:01 0.116 21.5 DQB1*03:04 0.003 0.7
A*02:24 0.002 0.3 B*14:02:01 0.025 5.0 C*04:01g 0.062 11.4 DRB1*04:02 0.008 1.7 DQB1*04:02 0.015 3.0
A*03:01g 0.138 25.5 B*15:01g 0.059 11.7 C*05:01g 0.102 19.5 DRB1*04:03:01 0.008 1.7 DQB1*05:01:01 0.112 20.5
A*03:02 0.003 0.7 B*15:03g 0.003 0.7 C*06:02 0.086 16.4 DRB1*04:04 0.047 9.4 DQB1*05:02:01 0.005 1.0
A*11:01g 0.070 13.1 B*15:07 0.002 0.3 C*07:01g 0.190 35.2 DRB1*04:05:01 0.002 0.3 DQB1*05:03:01 0.017 3.4
A*23:01g 0.018 3.7 B*15:16 0.002 0.3 C*07:02g 0.156 27.9 DRB1*04:06 0.002 0.3 DQB1*05:04 0.002 0.3
A*24:02g 0.069 13.8 B*15:17 0.003 0.7 C*07:04g 0.008 1.7 DRB1*04:07:01 0.012 2.3 DQB1*06:01 0.010 2.0
A*24:03g 0.002 0.3 B*15:18 0.003 0.7 C*08:02 0.032 6.4 DRB1*04:08 0.005 1.0 DQB1*06:02:01 0.149 27.5
A*25:01g 0.022 4.4 B*18:01g 0.045 9.1 C*08:03:01 0.002 0.3 DRB1*07:01:01 0.156 28.9 DQB1*06:03:01 0.055 11.1
A*26:01g 0.020 4.0 B*27:05g 0.042 8.1 C*12:02 0.010 2.0 DRB1*08:01 0.013 2.7 DQB1*06:04g 0.022 4.4
A*29:01g 0.003 0.7 B*35:01g 0.032 6.4 C*12:03 0.047 9.4 DRB1*08:03:02 0.003 0.7 DQB1*06:09 0.017 3.0
A*29:02:01 0.032 6.4 B*35:02:01 0.003 0.7 C*14:02:01 0.010 2.0 DRB1*09:01:02 0.012 2.3   1.000  
A*30:01g 0.007 1.3 B*35:03g 0.012 2.3 C*15:02g 0.023 4.7 DRB1*10:01:01 0.007 1.3    
A*30:02 0.010 2.0 B*35:08:01 0.003 0.7 C*15:05 0.003 0.7 DRB1*11:01 0.034 6.4    
A*31:01g 0.029 5.7 B*37:01:01 0.018 3.7 C*16:01:01 0.045 9.1 DRB1*11:02:01 0.002 0.3    
A*32:01 0.027 5.4 B*38:01:01 0.010 2.0 C*16:02 0.003 0.7 DRB1*11:03 0.008 1.7    
A*33:01 0.003 0.7 B*39:01g 0.007 1.3 C*17:01g 0.002 0.3 DRB1*11:04:01 0.008 1.7    
A*33:03g 0.003 0.7 B*39:06:02 0.002 0.3   1.000   DRB1*12:01g 0.010 2.0    
A*66:01g 0.005 1.0 B*40:01g 0.060 11.4     DRB1*13:01:01 0.045 9.1    
A*68:01g 0.018 3.7 B*40:02g 0.005 1.0     DRB1*13:02:01 0.039 7.0    
A*68:02 0.007 1.3 B*41:01 0.002 0.3     DRB1*13:03:01 0.003 0.7    
A*74:03 0.002 0.3 B*41:02:01 0.002 0.3     DRB1*13:05:01 0.003 0.7    
    B*44:02g 0.101 19.1     DRB1*14:01g 0.017 3.4    
    B*44:03 0.055 11.1     DRB1*15:01 0.159 28.9    
    B*44:04 0.002 0.3     DRB1*15:02:01 0.010 2.0    
    B*44:05 0.002 0.3     DRB1*16:01:01 0.002 0.3    
    B*45:01g 0.005 1.0     DRB1*16:02:01 0.003 0.7    
    B*47:01 0.005 1.0      1.000     
    B*48:01g 0.002 0.3          
    B*49:01 0.007 1.3          
    B*50:01 0.017 3.4          
    B*50:02 0.002 0.3          
    B*51:01g 0.047 9.4          
    B*52:01g 0.010 2.0          
    B*53:01:01 0.005 1.0          
    B*55:01 0.023 4.7          
    B*56:01g 0.008 1.7          
    B*57:01:01 0.037 7.0          
  1. AF, allele frequency; GF, genotype frequency (percentage of individuals carrying the allele). Alleles associated with DILI are shown in bold. Generic codes for ambiguities are denoted with the suffix 'g' (Table S5 in Additional file 1).