Relationships between miRNAs, diseases in which they are involved and populations. Heat maps were produced using an agglomerative clustering algorithm with Euclidean distances. (a) Heat map portraying the similarity between populations in terms of shared variants at each position of the miRNA precursor compared. The color code represents the number of common variants between population pairs. (b) Heat map of similarity between populations when only those positions mapping in the seed regions of the miRNAs are considered in the comparison. The color code represents the number of common variants between population pairs with the analysis restricted to variants mapping in the seed regions. (c) Heat map of the distribution of diseases across populations. The color code represents the number of variants per population associated with each disease category. (d) Hive plot showing the relationships between miRNAs, populations and diseases, with the diseases summarized in general categories.