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  • Erratum
  • Open Access

Erratum to: Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients

Contributed equally
Genome Medicine20179:61

  • Received: 16 June 2017
  • Accepted: 16 June 2017
  • Published:

The original article was published in Genome Medicine 2017 9:39


Following the publication of this article [1], it was brought to our attention that due to miscommunications in the production process, Fig. 1 labels were missing and Fig. 4 labelling was incorrect in the original online version.

The errors:
  1. 1.
    The x and y axis were accidentally omitted from Fig. 1c and d, as well as the key from 1b. The corrected Fig. 1 is presented below:
    Fig. 1
    Fig. 1

    Genus and species level differences in PD participants and controls. a NMDS ordination of all samples used in this study, using a Bray–Curtis between-sample distance at genus level. This shows the composition relatedness of samples and that PD samples form a subgroup. Outliers denoted with # took antibiotics in a period of 28–34 days prior to feces sampling. See also Additional file 2 for taxonomic analysis while taking these samples into account. b Genus-level sample composition. c The most significant species or groups of taxa that could not be further classified. Unclassified Prevotella is not significant after multiple testing, but was implied in PD in several studies (see “Discussion”). d Species correlating strongest to PD disease severity (as measured by UPDRS III). Note that after multiple testing correction, these are all q > 0.1

  2. 2.
    MaoB hemmer was erroneously used instead of the English term MaoB inhibitor in Fig. 4. The corrected Fig. 4 is presented below:
    Fig. 4
    Fig. 4

    Structural equation modeling (SEM). SEM analysis of PD in relation to key correlating bacterial functions and taxa (MSEA = 0, PCLOSE = 0.79, AIC = 59.385). Values on paths and boxes are standardized regression and determination coefficients (R2), respectively. Dashed lines and red colors denote negative relationships. The thickness of lines is proportional to regression coefficients. All relationships are statistically significant (P < 0.05, Additional file 5). AIC Akaike information criterion, MSEA mean square error of approximation, PCLOSE probability of close fit


The above errors have been corrected in the original version of this article [1].



Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

Department of Neurology, University of Bonn, Bonn, Germany
German Centre for neurodegenerative disease research (DZNE), Bonn, Germany
Department of Internal Medicine I, University of Bonn, Bonn, Germany
European Molecular Biology Laboratory, EMBL, Heidelberg, Germany
ETH Zurich, Institute of Microbiology, Vladimir-Prelog-1-5/10, 8093 Zurich, Switzerland
Molecular Medicine Partnership Unit (MMPU), University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany
Max Delbrück Centre for Molecular Medicine, 13125 Berlin, Germany
Department of Bioinformatics, University of Würzburg, 97074 Würzburg, Germany
Evolutionary Biology Centre, Uppsala University, Norbyva gen 18D, 75236 Uppsala, Sweden
Institute of Ecology and Earth Sciences, University of Tartu, 40 Lai St., 51005 Tartu, Estonia
German Center for Infection Research (DZIF), Bonn-Cologne, Germany
Sigmund-Freud-Str. 25, 53127 Bonn, Germany
Meyerhofstraße 1, 69117 Heidelberg, Germany


  1. Bedarf JR, et al. Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients. Genome Medicine. 2017;9:39. doi:10.1186/s13073-017-0428-y.View ArticlePubMedPubMed CentralGoogle Scholar


© The Author(s). 2017