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Open Access

Erratum to: Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients

Contributed equally
Genome Medicine20179:61

Received: 16 June 2017

Accepted: 16 June 2017

Published: 29 June 2017

The original article was published in Genome Medicine 2017 9:39


Following the publication of this article [1], it was brought to our attention that due to miscommunications in the production process, Fig. 1 labels were missing and Fig. 4 labelling was incorrect in the original online version.

The errors:
  1. 1.
    The x and y axis were accidentally omitted from Fig. 1c and d, as well as the key from 1b. The corrected Fig. 1 is presented below:
    Fig. 1

    Genus and species level differences in PD participants and controls. a NMDS ordination of all samples used in this study, using a Bray–Curtis between-sample distance at genus level. This shows the composition relatedness of samples and that PD samples form a subgroup. Outliers denoted with # took antibiotics in a period of 28–34 days prior to feces sampling. See also Additional file 2 for taxonomic analysis while taking these samples into account. b Genus-level sample composition. c The most significant species or groups of taxa that could not be further classified. Unclassified Prevotella is not significant after multiple testing, but was implied in PD in several studies (see “Discussion”). d Species correlating strongest to PD disease severity (as measured by UPDRS III). Note that after multiple testing correction, these are all q > 0.1

  2. 2.
    MaoB hemmer was erroneously used instead of the English term MaoB inhibitor in Fig. 4. The corrected Fig. 4 is presented below:
    Fig. 4

    Structural equation modeling (SEM). SEM analysis of PD in relation to key correlating bacterial functions and taxa (MSEA = 0, PCLOSE = 0.79, AIC = 59.385). Values on paths and boxes are standardized regression and determination coefficients (R2), respectively. Dashed lines and red colors denote negative relationships. The thickness of lines is proportional to regression coefficients. All relationships are statistically significant (P < 0.05, Additional file 5). AIC Akaike information criterion, MSEA mean square error of approximation, PCLOSE probability of close fit


The above errors have been corrected in the original version of this article [1].



Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

Department of Neurology, University of Bonn
German Centre for neurodegenerative disease research (DZNE)
Department of Internal Medicine I, University of Bonn
European Molecular Biology Laboratory, EMBL
ETH Zurich, Institute of Microbiology
Molecular Medicine Partnership Unit (MMPU), University of Heidelberg and European Molecular Biology Laboratory
Max Delbrück Centre for Molecular Medicine
Department of Bioinformatics, University of Würzburg
Evolutionary Biology Centre, Uppsala University
Institute of Ecology and Earth Sciences, University of Tartu
German Center for Infection Research (DZIF)


  1. Bedarf JR, et al. Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients. Genome Medicine. 2017;9:39. doi:10.1186/s13073-017-0428-y.View ArticlePubMedPubMed CentralGoogle Scholar


© The Author(s). 2017