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  1. We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disor...

    Authors: Jean Bousquet, Josep M Anto, Peter J Sterk, Ian M Adcock, Kian Fan Chung, Josep Roca, Alvar Agusti, Chris Brightling, Anne Cambon-Thomsen, Alfredo Cesario, Sonia Abdelhak, Stylianos E Antonarakis, Antoine Avignon, Andrea Ballabio, Eugenio Baraldi, Alexander Baranov…
    Citation: Genome Medicine 2011 3:43
    Content type: Correspondence Published on:

  3. Genome-wide association studies have identified several genomic regions that are associated with breast cancer risk, but these provide an explanation for only a small fraction of familial breast cancer aggrega...

    Authors: Ying Huang, Dennis G Ballinger, James Y Dai, Ulrike Peters, David A Hinds, David R Cox, Erica Beilharz, Rowan T Chlebowski, Jacques E Rossouw, Anne McTiernan, Thomas Rohan and Ross L Prentice
    Citation: Genome Medicine 2011 3:42
    Content type: Research Published on:

    The Erratum to this article has been published in Genome Medicine 2012 4:19

  4. Embryonic stem cell specific microRNAs (miRNAs) have previously been shown to enhance the efficiency of transcription-factor-based reprogramming. However, whether reprogramming could be achieved entirely by mi...

    Authors: Tamer T Onder and George Q Daley
    Citation: Genome Medicine 2011 3:40
    Content type: Research highlight Published on:

  6. Achieving 'personalized medicine' requires enrolling representative cohorts into genetic studies, but patient self-selection may introduce bias. We sought to identify characteristics associated with genetic co...

    Authors: David E Lanfear, Philip G Jones, Sharon Cresci, Fengming Tang, Saif S Rathore and John A Spertus
    Citation: Genome Medicine 2011 3:39
    Content type: Research Published on:

  8. Human pluripotent cells such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) and their in vitro differentiation models hold great promise for regenerative medicine as they provide...

    Authors: Alvaro Rada-Iglesias and Joanna Wysocka
    Citation: Genome Medicine 2011 3:36
    Content type: Review Published on:

  11. In order to identify novel loci associated with Alzheimer's disease (AD), we conducted a genome-wide association study (GWAS) in the Spanish population.

    Authors: Carmen Antúnez, Mercè Boada, Antonio González-Pérez, Javier Gayán, Reposo Ramírez-Lorca, Juan Marín, Isabel Hernández, Concha Moreno-Rey, Francisco Jesús Morón, Jesús López-Arrieta, Ana Mauleón, Maitée Rosende-Roca, Fuensanta Noguera-Perea, Agustina Legaz-García, Laura Vivancos-Moreau, Juan Velasco…
    Citation: Genome Medicine 2011 3:33
    Content type: Research Published on:

  13. Systemic lupus erythematosus is a systemic, heterogeneous autoimmune disease. Understanding of its molecular complexity is incomplete and there is a need to identify new therapeutic targets and to optimize cri...

    Authors: Cornelis L Verweij and Saskia Vosslamber
    Citation: Genome Medicine 2011 3:30
    Content type: Research highlight Published on:

  14. A report on the 'Genomic Disorders 2011 - The Genomics of Rare Diseases' meeting, Wellcome Trust Sanger Institute, Hinxton, UK, 23-26 March 2011

    Authors: Kathleen H Burns and Aravinda Chakravarti
    Citation: Genome Medicine 2011 3:29
    Content type: Meeting report Published on:

  15. The anticonvulsant carbamazepine has a high incidence of cutaneous adverse drug reactions. A recent prospective clinical trial in Taiwan has indicated that HLA-B*1502 screening will reduce the incidence of life-t...

    Authors: Taisei Mushiroda and Yusuke Nakamura
    Citation: Genome Medicine 2011 3:28
    Content type: Research highlight Published on:

  16. Colorectal cancer (CRC) is a heterogeneous disease that, on the molecular level, can be characterized by inherent genomic instabilities; chromosome instability and microsatellite instability. In the present st...

    Authors: Anita Sveen, Trude H Ågesen, Arild Nesbakken, Torleiv O Rognum, Ragnhild A Lothe and Rolf I Skotheim
    Citation: Genome Medicine 2011 3:32
    Content type: Research Published on:

  20. The study of rare variants holds the promise of accounting for some of the missing heritability in complex traits. Next-generation sequencing technologies enable probing of variation across the full spectrum o...

    Authors: Jennifer Asimit and Eleftheria Zeggini
    Citation: Genome Medicine 2011 3:24
    Content type: Research highlight Published on:

  26. Persons with schizophrenia and other psychotic disorders have a high prevalence of obesity, impaired glucose tolerance, and lipid abnormalities, particularly hypertriglyceridemia and low high-density lipoprote...

    Authors: Matej Orešič, Jing Tang, Tuulikki Seppänen-Laakso, Ismo Mattila, Suoma E Saarni, Samuli I Saarni, Jouko Lönnqvist, Marko Sysi-Aho, Tuulia Hyötyläinen, Jonna Perälä and Jaana Suvisaari
    Citation: Genome Medicine 2011 3:19
    Content type: Research Published on:

  27. Plausible genome-wide associations for episodic neurological diseases (such as migraine, epilepsy and ataxias) have been slow to emerge. The first such association was reported in a recent genome-wide associat...

    Authors: Verneri Anttila, Maija Wessman, Mikko Kallela and Aarno Palotie
    Citation: Genome Medicine 2011 3:17
    Content type: Research highlight Published on:

  28. The rapid and continuing progress in gene discovery for complex diseases is fueling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies a...

    Authors: A Cecile JW Janssens, John PA Ioannidis, Cornelia M van Duijn, Julian Little and Muin J Khoury
    Citation: Genome Medicine 2011 3:16
    Content type: Correspondence Published on:

  30. The gut microbiome is the term given to describe the vast collection of symbiotic microorganisms in the human gastrointestinal system and their collective interacting genomes. Recent studies have suggested tha...

    Authors: James M Kinross, Ara W Darzi and Jeremy K Nicholson
    Citation: Genome Medicine 2011 3:14
    Content type: Review Published on:

  33. There has been considerable interest in cancer stem cells (CSCs) among cancer biologists and clinicians, most likely because of their role in the heterogeneity of cancer and their potential application in canc...

    Authors: Bo Wang and Samson T Jacob
    Citation: Genome Medicine 2011 3:11
    Content type: Review Published on:

  35. The risk of certain birth defects can be modified by maternal diet. A high-fat maternal mouse diet has recently been reported to substantially increase the penetrance of birth defects known to be associated wi...

    Authors: Krista S Crider and Lynn B Bailey
    Citation: Genome Medicine 2011 3:9
    Content type: Commentary Published on:

  36. Chronic hepatitis C virus (HCV) infection is a major cause of liver disease worldwide. HCV infection is currently treated with IFNα plus ribavirin for 24 to 48 weeks. This demanding therapy fails in up to 50% ...

    Authors: John E Tavis, Maureen J Donlin, Rajeev Aurora, Xiaofeng Fan and Adrian M Di Bisceglie
    Citation: Genome Medicine 2011 3:8
    Content type: Review Published on:

  42. Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated pe...

    Authors: Christian P Kratz, Gennady Bratslavsky and Jianxin Shi
    Citation: Genome Medicine 2011 3:1
    Content type: Commentary Published on:

  43. Multiple sclerosis (MS) is the most common cause of chronic neurologic disability beginning in early to middle adult life. Results from recent genome-wide association studies (GWAS) have substantially lengthen...

    Authors: Joanne H Wang, Derek Pappas, Philip L De Jager, Daniel Pelletier, Paul IW de Bakker, Ludwig Kappos, Chris H Polman, Lori B Chibnik, David A Hafler, Paul M Matthews, Stephen L Hauser, Sergio E Baranzini and Jorge R Oksenberg
    Citation: Genome Medicine 2011 3:3
    Content type: Research Published on:

  44. Cell type heterogeneity may have a substantial effect on gene expression profiling of human tissue. Several in silico methods for deconvoluting a gene expression profile into cell-type-specific subprofiles have b...

    Authors: Yingdong Zhao and Richard Simon
    Citation: Genome Medicine 2010 2:93
    Content type: Commentary Published on:

  49. Cystic fibrosis is one of the most common life-limiting inherited disorders. Its clinical impact manifests chiefly in the lung, pancreas, gastrointestinal tract and sweat glands, with lung disease typically be...

    Authors: Sally H Pattison and J Stuart Elborn
    Citation: Genome Medicine 2010 2:88
    Content type: Review Published on:
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Genome Medicine

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