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  1. A gluten-free diet (GFD) is the most commonly adopted special diet worldwide. It is an effective treatment for coeliac disease and is also often followed by individuals to alleviate gastrointestinal complaints...

    Authors: Marc Jan Bonder, Ettje F. Tigchelaar, Xianghang Cai, Gosia Trynka, Maria C. Cenit, Barbara Hrdlickova, Huanzi Zhong, Tommi Vatanen, Dirk Gevers, Cisca Wijmenga, Yang Wang and Alexandra Zhernakova
    Citation: Genome Medicine 2016 8:45
    Content type: Research Published on:

  2. The oral cavity is home to one of the most diverse microbial communities of the human body and a major entry portal for pathogens. Its homeostasis is maintained by saliva, which fulfills key functions includin...

    Authors: Niklas Grassl, Nils Alexander Kulak, Garwin Pichler, Philipp Emanuel Geyer, Jette Jung, Sören Schubert, Pavel Sinitcyn, Juergen Cox and Matthias Mann
    Citation: Genome Medicine 2016 8:44
    Content type: Research Published on:

  3. The adaptive immune response in rheumatoid arthritis (RA) is influenced by an interaction between host genetics and environment, particularly the host microbiome. Association of the gut microbiota with various...

    Authors: Jun Chen, Kerry Wright, John M. Davis, Patricio Jeraldo, Eric V. Marietta, Joseph Murray, Heidi Nelson, Eric L. Matteson and Veena Taneja
    Citation: Genome Medicine 2016 8:43
    Content type: Research Published on:

  4. The human gut harbors more than 100 trillion microbial cells, which have an essential role in human metabolic regulation via their symbiotic interactions with the host. Altered gut microbial ecosystems have be...

    Authors: Claire L. Boulangé, Ana Luisa Neves, Julien Chilloux, Jeremy K. Nicholson and Marc-Emmanuel Dumas
    Citation: Genome Medicine 2016 8:42
    Content type: Review Published on:

  6. Infections encountered in the cancer setting may arise from intensive cancer treatments or may result from the cancer itself, leading to risk of infections through immune compromise, disruption of anatomic bar...

    Authors: Ying Taur and Eric G. Pamer
    Citation: Genome Medicine 2016 8:40
    Content type: Review Published on:

  8. Colorectal cancer (CRC) is the second leading cause of death among cancers in the United States. Although individuals diagnosed early have a greater than 90 % chance of survival, more than one-third of individ...

    Authors: Nielson T. Baxter, Mack T. Ruffin IV, Mary A. M. Rogers and Patrick D. Schloss
    Citation: Genome Medicine 2016 8:37
    Content type: Research Published on:

  9. There is a growing realization that the gut–brain axis plays a key role in maintaining brain health and the stress response. Recently, the gut microbiota has emerged as a master regulator of this axis. Thus, o...

    Authors: Timothy G. Dinan and John F. Cryan
    Citation: Genome Medicine 2016 8:36
    Content type: Comment Published on:

  10. Management, manipulation, and restoration of a robust vaginal microbiota has the potential to vastly improve women’s health and disease prevention. However, a systems level understanding of how the vaginal mic...

    Authors: Jacques Ravel and Rebecca M. Brotman
    Citation: Genome Medicine 2016 8:35
    Content type: Comment Published on:

  12. More accurate diagnostic methods are pressingly needed to diagnose breast cancer, the most common malignant cancer in women worldwide. Blood-based metabolomics is a promising diagnostic method for breast cance...

    Authors: Sijia Huang, Nicole Chong, Nathan E. Lewis, Wei Jia, Guoxiang Xie and Lana X. Garmire
    Citation: Genome Medicine 2016 8:34
    Content type: Research Published on:

  14. Hepatic fibrosis is the underlying cause of cirrhosis and liver failure in nearly every form of chronic liver disease, and hepatic stellate cells (HSCs) are the primary cell type responsible for fibrosis. Long...

    Authors: Chan Zhou, Samuel R. York, Jennifer Y. Chen, Joshua V. Pondick, Daniel L. Motola, Raymond T. Chung and Alan C. Mullen
    Citation: Genome Medicine 2016 8:31
    Content type: Research Published on:

  17. NF-κB is widely involved in lymphoid malignancies; however, the functional roles and specific transcriptomes of NF-κB dimers with distinct subunit compositions have been unclear.

    Authors: Kivia A. P. de Oliveira, Eva Kaergel, Matthias Heinig, Jean-Fred Fontaine, Giannino Patone, Enrique M. Muro, Stephan Mathas, Michael Hummel, Miguel A. Andrade-Navarro, Norbert Hübner and Claus Scheidereit
    Citation: Genome Medicine 2016 8:28
    Content type: Research Published on:

  19. Limited treatment options are available for patients infected with multidrug (MDR)- or pan-drug (PDR)-resistant bacterial pathogens, resulting in infections that can persist for weeks or months. In order to be...

    Authors: Meredith S. Wright, Alina Iovleva, Michael R. Jacobs, Robert A. Bonomo and Mark D. Adams
    Citation: Genome Medicine 2016 8:26
    Content type: Research Published on:

  20. The editors of Genome Medicine are extremely grateful for the time, hard work and support of all our reviewers, and would like to thank everyone who contributed to the journal in Volume 7 (2015).

    Authors: Rebecca F Furlong
    Citation: Genome Medicine 2016 8:25
    Content type: Reviewer acknowledgement Published on:

  21. As whole exome sequencing (WES) and whole genome sequencing (WGS) transition from research tools to clinical diagnostic tests, it is increasingly critical for sequencing methods and analysis pipelines to be te...

    Authors: Rachel L. Goldfeder, James R. Priest, Justin M. Zook, Megan E. Grove, Daryl Waggott, Matthew T. Wheeler, Marc Salit and Euan A. Ashley
    Citation: Genome Medicine 2016 8:24
    Content type: Research Published on:

  22. The study of human B cell response to dengue virus (DENV) infection is critical to understand serotype-specific protection and the cross-reactive sub-neutralizing response. Whereas the first is beneficial and ...

    Authors: Elizabeth Ernestina Godoy-Lozano, Juan Téllez-Sosa, Gilberto Sánchez-González, Hugo Sámano-Sánchez, Andrés Aguilar-Salgado, Aarón Salinas-Rodríguez, Bernardo Cortina-Ceballos, Héctor Vivanco-Cid, Karina Hernández-Flores, Jennifer M. Pfaff, Kristen M. Kahle, Benjamin J. Doranz, Rosa Elena Gómez-Barreto, Humberto Valdovinos-Torres, Irma López-Martínez, Mario H. Rodriguez…
    Citation: Genome Medicine 2016 8:23
    Content type: Research Published on:

  27. Obesity and type 2 diabetes (T2D) are linked both with host genetics and with environmental factors, including dysbioses of the gut microbiota. However, it is unclear whether these microbial changes precede di...

    Authors: Moran Yassour, Mi Young Lim, Hyun Sun Yun, Timothy L. Tickle, Joohon Sung, Yun-Mi Song, Kayoung Lee, Eric A. Franzosa, Xochitl C. Morgan, Dirk Gevers, Eric S. Lander, Ramnik J. Xavier, Bruce W. Birren, GwangPyo Ko and Curtis Huttenhower
    Citation: Genome Medicine 2016 8:17
    Content type: Research Published on:

  28. Nuclease-based technologies have been developed that enable targeting of specific DNA sequences directly in the zygote. These approaches provide an opportunity to modify the genomes of inbred mice, and allow t...

    Authors: Joffrey Mianné, Lauren Chessum, Saumya Kumar, Carlos Aguilar, Gemma Codner, Marie Hutchison, Andrew Parker, Ann-Marie Mallon, Sara Wells, Michelle M. Simon, Lydia Teboul, Steve D. M. Brown and Michael R. Bowl
    Citation: Genome Medicine 2016 8:16
    Content type: Research Published on:

  29. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common healthcare-associated pathogens. To examine the role of inter-hospital patient sharing on MRSA transmission, a previous study collected...

    Authors: Hsiao-Han Chang, Janina Dordel, Tjibbe Donker, Colin J. Worby, Edward J. Feil, William P. Hanage, Stephen D. Bentley, Susan S. Huang and Marc Lipsitch
    Citation: Genome Medicine 2016 8:18
    Content type: Research Published on:

  30. Inter-tissue molecular interactions are critical to the function and behavior of biological systems in multicellular organisms, but systematic studies of interactions between tissues are lacking. Also, existin...

    Authors: Quan Long, Carmen Argmann, Sander M. Houten, Tao Huang, Siwu Peng, Yong Zhao, Zhidong Tu and Jun Zhu
    Citation: Genome Medicine 2016 8:15
    Content type: Research Published on:

  32. Genome-wide data are increasingly important in the clinical evaluation of human disease. However, the large number of variants observed in individual patients challenges the efficiency and accuracy of diagnost...

    Authors: Regis A. James, Ian M. Campbell, Edward S. Chen, Philip M. Boone, Mitchell A. Rao, Matthew N. Bainbridge, James R. Lupski, Yaping Yang, Christine M. Eng, Jennifer E. Posey and Chad A. Shaw
    Citation: Genome Medicine 2016 8:13
    Content type: Research Published on:

  34. Cancer immunotherapy has gained significant momentum from recent clinical successes of checkpoint blockade inhibition. Massively parallel sequence analysis suggests a connection between mutational load and res...

    Authors: Jasreet Hundal, Beatriz M. Carreno, Allegra A. Petti, Gerald P. Linette, Obi L. Griffith, Elaine R. Mardis and Malachi Griffith
    Citation: Genome Medicine 2016 8:11
    Content type: Method Published on:

  35. Frailty is arguably the biggest problem associated with population ageing, and associates with gut microbiome composition in elderly and care-dependent individuals. Here we characterize frailty associations wi...

    Authors: Matthew A. Jackson, Ian B. Jeffery, Michelle Beaumont, Jordana T. Bell, Andrew G. Clark, Ruth E. Ley, Paul W. O’Toole, Tim D. Spector and Claire J. Steves
    Citation: Genome Medicine 2016 8:8
    Content type: Research Published on:

    The Erratum to this article has been published in Genome Medicine 2016 8:21

  37. String-of-beads polypeptides allow convenient delivery of epitope-based vaccines. The success of a polypeptide relies on efficient processing: constituent epitopes need to be recovered while avoiding neo-epito...

    Authors: Benjamin Schubert and Oliver Kohlbacher
    Citation: Genome Medicine 2016 8:9
    Content type: Method Published on:

  38. Progress in personalized medicine is now being translated to personalized nutrition. A recent proof-of-concept study shows that the increase in blood glucose levels after a meal is highly variable between indi...

    Authors: Marc-Emmanuel Dumas
    Citation: Genome Medicine 2016 8:7
    Content type: Research Highlight Published on:

  40. Alzheimer’s disease affects ~13 % of people in the United States 65 years and older, making it the most common neurodegenerative disorder. Recent work has identified roles for environmental, genetic, and epige...

    Authors: Corey T. Watson, Panos Roussos, Paras Garg, Daniel J. Ho, Nidha Azam, Pavel L. Katsel, Vahram Haroutunian and Andrew J. Sharp
    Citation: Genome Medicine 2016 8:5
    Content type: Research Published on:

  41. Bacterial whole-genome sequencing (WGS) has the potential to identify reservoirs of multidrug-resistant organisms and transmission of these pathogens across healthcare networks. We used WGS to define transmiss...

    Authors: Hayley J. Brodrick, Kathy E. Raven, Ewan M. Harrison, Beth Blane, Sandra Reuter, M. Estée Török, Julian Parkhill and Sharon J. Peacock
    Citation: Genome Medicine 2016 8:4
    Content type: Research Published on:

  42. Authors: Alexander L. Greninger, Kevin Messacar, Thelma Dunnebacke, Samia N. Naccache, Scot Federman, Jerome Bouquet, David Mirsky, Yosuke Nomura, Shigeo Yagi, Carol Glaser, Michael Vollmer, Craig A. Press, Bette K. Kleinschmidt-DeMasters, Samuel R. Dominguez and Charles Y. Chiu
    Citation: Genome Medicine 2016 8:1
    Content type: Erratum Published on:

    The original article was published in Genome Medicine 2015 7:113

  43. Large-scale cohort-based whole exome sequencing of individuals with neurodevelopmental disorders (NDDs) has identified numerous novel candidate disease genes; however, detailed phenotypic information is often ...

    Authors: Janson White, Christine R. Beck, Tamar Harel, Jennifer E. Posey, Shalini N. Jhangiani, Sha Tang, Kelly D. Farwell, Zöe Powis, Nancy J. Mendelsohn, Janice A. Baker, Lynda Pollack, Kati J. Mason, Klaas J. Wierenga, Daniel K. Arrington, Melissa Hall, Apostolos Psychogios…
    Citation: Genome Medicine 2016 8:3
    Content type: Research Published on:

  44. Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response. Previous genome-wide studies have focuse...

    Authors: Stephane Bourgeois, Andrea Jorgensen, Eunice J. Zhang, Anita Hanson, Matthew S. Gillman, Suzannah Bumpstead, Cheng Hock Toh, Paula Williamson, Ann K. Daly, Farhad Kamali, Panos Deloukas and Munir Pirmohamed
    Citation: Genome Medicine 2016 8:2
    Content type: Research Published on:

  47. Hemophagocytic lymphohistiocytosis (HLH) is a rapid-onset, potentially fatal hyperinflammatory syndrome. A prompt molecular diagnosis is crucial for appropriate clinical management. Here, we validated and pros...

    Authors: Bianca Tesi, Kristina Lagerstedt-Robinson, Samuel C. C. Chiang, Eya Ben Bdira, Miguel Abboud, Burcu Belen, Omer Devecioglu, Zehra Fadoo, Allen E. J. Yeoh, Hans Christian Erichsen, Merja Möttönen, Himmet Haluk Akar, Johanna Hästbacka, Zuhre Kaya, Susana Nunes, Turkan Patiroglu…
    Citation: Genome Medicine 2015 7:130
    Content type: Research Published on:

  49. Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for many hematological conditions. Acute graft-versus-host disease (aGVHD) is a prevalent immune-mediated complication followin...

    Authors: Dirk S. Paul, Allison Jones, Rob S. Sellar, Neema P. Mayor, Andrew Feber, Amy P. Webster, Neuza Afonso, Ruhena Sergeant, Richard M. Szydlo, Jane F. Apperley, Martin Widschwendter, Stephen Mackinnon, Steven G. E. Marsh, J. Alejandro Madrigal, Vardhman K. Rakyan, Karl S. Peggs…
    Citation: Genome Medicine 2015 7:128
    Content type: Research Published on:

  50. Association studies have identified a number of loci that contribute to an increased body mass index (BMI), the strongest of which is in the first intron of the FTO gene on human chromosome 16q12.2. However, t...

    Authors: Lilian E. Hunt, Boris Noyvert, Leena Bhaw-Rosun, Abdul K. Sesay, Lavinia Paternoster, Ellen A. Nohr, George Davey Smith, Niels Tommerup, Thorkild I. A. Sørensen and Greg Elgar
    Citation: Genome Medicine 2015 7:126
    Content type: Research Published on:
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Genome Medicine

ISSN: 1756-994X

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