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  1. Specific language impairment (SLI) is defined as an unexpected and persistent impairment in language ability despite adequate opportunity and intelligence and in the absence of any explanatory medical conditio...

    Authors: Dianne F Newbury, Simon E Fisher and Anthony P Monaco

    Citation: Genome Medicine 2010 2:6

    Content type: Review

    Published on:

  2. Genome-wide association studies have detected dozens of variants underlying complex diseases, although it is uncertain how often these discoveries will translate into clinically useful predictors. Here, to imp...

    Authors: Douglas M Ruderfer, Joshua Korn and Shaun M Purcell

    Citation: Genome Medicine 2010 2:2

    Content type: Method

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  3. Cancer cachexia is a multi-organ tissue wasting syndrome that contributes to morbidity and mortality in many cancer patients. Skeletal muscle loss represents an established key feature yet there is no molecula...

    Authors: Nathan A Stephens, Iain J Gallagher, Olav Rooyackers, Richard J Skipworth, Ben H Tan, Troels Marstrand, James A Ross, Denis C Guttridge, Lars Lundell, Kenneth C Fearon and James A Timmons

    Citation: Genome Medicine 2010 2:1

    Content type: Research

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  4. Although statins are generally well tolerated, the most common adverse drug reaction from statin therapy is myopathy. This article reviews the current pharmacogenomic knowledge of statin-induced myopathy. Furt...

    Authors: Bas JM Peters, Olaf H Klungel, Frank L Visseren, Anthonius de Boer and Anke-Hilse Maitland-van der Zee

    Citation: Genome Medicine 2009 1:120

    Content type: Review

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  5. Public health preparedness requires effective surveillance of and rapid response to infectious disease outbreaks. Inclusion of research activities within the outbreak setting provides important opportunities t...

    Authors: Nicole F Dowling, Marta Gwinn and Alison Mawle

    Citation: Genome Medicine 2009 1:119

    Content type: Commentary

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  6. Women's Health Initiative randomized trials of postmenopausal hormone therapy reported intervention effects on several clinical outcomes, with some important differences between estrogen alone and estrogen plu...

    Authors: Sharon J Pitteri, Samir M Hanash, Aaron Aragaki, Lynn M Amon, Lin Chen, Tina Busald Buson, Sophie Paczesny, Hiroyuki Katayama, Hong Wang, Melissa M Johnson, Qing Zhang, Martin McIntosh, Pei Wang, Charles Kooperberg, Jacques E Rossouw, Rebecca D Jackson…

    Citation: Genome Medicine 2009 1:121

    Content type: Research

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  7. The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and members of the nuclear receptor superfamily. The PPAR family consists of three members: PPARα, PPARγ, and ...

    Authors: Lee D Roberts, David G Hassall, Deborah A Winegar, John N Haselden, Andrew W Nicholls and Julian L Griffin

    Citation: Genome Medicine 2009 1:115

    Content type: Research

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  8. Chronic obstructive pulmonary disease (COPD) is a common problem worldwide, and it is recognized that the term encompasses overlapping sub-phenotypes of disease. The development of a sub-phenotype may be deter...

    Authors: Alice M Wood, See Ling Tan and Robert A Stockley

    Citation: Genome Medicine 2009 1:112

    Content type: Review

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  9. Genomic data often persist far beyond the initial study in which they were generated. But the true value of the data is tied to their being both used and useful, and the usefulness of the data relies intimatel...

    Authors: John Quackenbush

    Citation: Genome Medicine 2009 1:111

    Content type: Commentary

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  10. Although the literature concerning statistical testing for genotype-phenotype association in family-based and population-based studies is very extensive, until recently the sex chromosomes have received little...

    Authors: David G Clayton

    Citation: Genome Medicine 2009 1:110

    Content type: Review

    Published on:

  11. A function for the microRNA (miRNA) pathway in vascular development and angiogenesis has been firmly established. miRNAs with selective expression in the vasculature are attractive as possible targets in miRNA...

    Authors: Erik Larsson, Peder Fredlund Fuchs, Johan Heldin, Irmeli Barkefors, Cecilia Bondjers, Guillem Genové, Christelle Arrondel, Pär Gerwins, Christine Kurschat, Bernhard Schermer, Thomas Benzing, Scott J Harvey, Johan Kreuger and Per Lindahl

    Citation: Genome Medicine 2009 1:108

    Content type: Research

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  12. The inflammatory bowel diseases, Crohn's disease and ulcerative colitis, pose a fascinating challenge to specialists in gastroenterology, infectious diseases, immunology and genetics and an often crushing burd...

    Authors: David G Nathan and Stuart H Orkin

    Citation: Genome Medicine 2009 1:103

    Content type: Musings

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  13. Technological advances have enabled a better characterization of all the genetic alterations in tumors. A picture that emerges is that tumor cells are much more genetically heterogeneous than originally expect...

    Authors: Sandro J de Souza, Beatriz Stransky and Anamaria A Camargo

    Citation: Genome Medicine 2009 1:101

    Content type: Minireview

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  14. Genome-wide association studies are the most comprehensive and straightforward approach to teasing out the identity of genetic polymorphisms associated with any given disease or characteristic. With the availa...

    Authors: Bruce N Cronstein

    Citation: Genome Medicine 2009 1:98

    Content type: Minireview

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  15. Transposable elements (TEs) have been consistently underestimated in their contribution to genetic instability and human disease. TEs can cause human disease by creating insertional mutations in genes, and als...

    Authors: Victoria P Belancio, Prescott L Deininger and Astrid M Roy-Engel

    Citation: Genome Medicine 2009 1:97

    Content type: Review

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  16. Mitochondrial disorders can originate from mutations in one of many nuclear genes controlling the organelle function or in the mitochondrial genome (mitochondrial DNA (mtDNA)). The large numbers of potential c...

    Authors: Valeria Vasta, Sarah B Ng, Emily H Turner, Jay Shendure and Si Houn Hahn

    Citation: Genome Medicine 2009 1:100

    Content type: Research

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  17. In June 2009, the Science and Technology Committee of the UK House of Lords published a report on genomic medicine, based on expert evidence collected over an 18-month period. Crucially, the report signaled th...

    Authors: Hilary Burton, Caroline F Wright and Ron Zimmern

    Citation: Genome Medicine 2009 1:93

    Content type: Commentary

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  18. Systems biology has matured considerably as a discipline over the last decade, yet some of the key challenges separating current research efforts in systems biology and clinically useful results are only now b...

    Authors: Gilles Clermont, Charles Auffray, Yves Moreau, David M Rocke, Daniel Dalevi, Devdatt Dubhashi, Dana R Marshall, Peter Raasch, Frank Dehne, Paolo Provero, Jesper Tegner, Bruce J Aronow, Michael A Langston and Mikael Benson

    Citation: Genome Medicine 2009 1:88

    Content type: Correspondence

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  19. Translation of research findings into clinical practice is an important aspect of medical progress. Even for the early stages of genomics, research aiming to deepen understandings of underlying mechanisms of d...

    Authors: Naomi Hawkins, Jantina de Vries, Paula Boddington, Jane Kaye and Catherine Heeney

    Citation: Genome Medicine 2009 1:87

    Content type: Correspondence

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  20. Gene patents have generally not impeded biomedical research, but some problems that arise in genetic diagnostics can be attributed to exclusively licensed gene patents. Gene patents for therapeutics have often...

    Authors: Subhashini Chandrasekharan and Robert Cook-Deegan

    Citation: Genome Medicine 2009 1:92

    Content type: Commentary

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  21. A major transition in human population structure is currently under way, moving from a historical metapopulation, comprising small and mainly rural endogamous communities, to large and increasingly panmictic u...

    Authors: Harry Campbell, Igor Rudan, Alan H Bittles and Alan F Wright

    Citation: Genome Medicine 2009 1:91

    Content type: Commentary

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  22. Recent studies have demonstrated that network approaches are highly appropriate tools for understanding the extreme complexity of the aging process. Moreover, the generality of the network concept helps to def...

    Authors: Gábor I Simkó, Dávid Gyurkó, Dániel V Veres, Tibor Nánási and Peter Csermely

    Citation: Genome Medicine 2009 1:90

    Content type: Review

    Published on:

  23. From the point of view of genome medicine, Barack Obama has made two vital policy decisions: he has chosen a new director of the National Institutes of Health, and his proposed change in United States healthca...

    Authors: David G Nathan and Stuart H Orkin

    Citation: Genome Medicine 2009 1:86

    Content type: Musings

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  24. The need for an integrated view of data obtained from high-throughput technologies gave rise to network analyses. These are especially useful to rationalize how external perturbations propagate through the exp...

    Authors: Elisabet Selga, Carlota Oleaga, Sara Ramírez, M Cristina de Almagro, Véronique Noé and Carlos J Ciudad

    Citation: Genome Medicine 2009 1:83

    Content type: Research

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  25. Granulosa cell tumors (GCTs) of the ovary belong to the group of ovarian sex-cord stromal tumors and represent 5 to 10% of ovarian malignancies. GCTs exhibit several morphological, biochemical and hormonal fea...

    Authors: Nicolas Kalfa, Reiner A Veitia, Bérénice A Benayoun, Brigitte Boizet-Bonhoure and Charles Sultan

    Citation: Genome Medicine 2009 1:81

    Content type: Minireview

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  26. For almost three decades, Huntington's disease has been a prototype for the application of genetic strategies to human disease. HD, the Huntington's disease gene, was the first autosomal defect mapped using only ...

    Authors: James F Gusella and Marcy E MacDonald

    Citation: Genome Medicine 2009 1:80

    Content type: Review

    Published on:

  27. Since the 1950s, lithium salts have been the main line of treatment for bipolar disorder (BD), both as a prophylactic and as an episodic treatment agent. Like many psychiatric conditions, BD is genetically and...

    Authors: Cristiana Cruceanu, Martin Alda and Gustavo Turecki

    Citation: Genome Medicine 2009 1:79

    Content type: Review

    Published on:

  28. Genome-wide association analyses on large patient cohorts are generating large sets of candidate disease genes. This is coupled with the availability of ever-increasing genomic databases and a rapidly expandin...

    Authors: Nicki Tiffin, Miguel A Andrade-Navarro and Carolina Perez-Iratxeta

    Citation: Genome Medicine 2009 1:77

    Content type: Review

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  29. The age at natural menopause shows great variability. It has been proposed that early age at menopause is a risk factor for osteoporosis and cardiovascular disease, whereas later age at menopause is a risk fac...

    Authors: Francisco Jesus Moron, Agustin Ruiz and Jose Jorge Galan

    Citation: Genome Medicine 2009 1:76

    Content type: Minireview

    Published on:

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