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  1. Targeted therapy with tyrosine kinase inhibitors has led to a substantial improvement in the standard of care for patients with advanced or metastatic clear cell renal cell carcinoma. Because the mechanism of ...

    Authors: Ram N Ganapathi and Ronald M Bukowski
    Citation: Genome Medicine 2011 3:79
    Content type: Research highlight Published on:

  4. Fragile X syndrome is the most common cause of inherited intellectual disability, but the underlying pathophysiology is complex and effective treatments are lacking. In a recent study of fragile X mental retardat...

    Authors: Inge Heulens, Sien Braat and R Frank Kooy
    Citation: Genome Medicine 2011 3:80
    Content type: Research highlight Published on:

  6. Organic cation transporters (OCTs) determine not only physiological processes but are also involved in the cellular uptake of anticancer agents. Based on microarray analyses in hepatocellular carcinoma (HCC), SLC...

    Authors: Elke Schaeffeler, Claus Hellerbrand, Anne T Nies, Stefan Winter, Stephan Kruck, Ute Hofmann, Heiko van der Kuip, Ulrich M Zanger, Hermann Koepsell and Matthias Schwab
    Citation: Genome Medicine 2011 3:82
    Content type: Research Published on:

  9. Glioblastoma multiforme (GBM) is the most common, aggressive and malignant primary tumor of the brain and is associated with one of the worst 5-year survival rates among all human cancers. Identification of mo...

    Authors: Rotem Ben-Hamo and Sol Efroni
    Citation: Genome Medicine 2011 3:77
    Content type: Research Published on:

    The Erratum to this article has been published in Genome Medicine 2012 4:87

  10. MicroRNAs are post-transcriptional regulators that are involved in many physiological and pathophysiological conditions. A recent study compared the expression profiles of hundreds of blood-borne microRNAs acr...

    Authors: Nathalie Schöler, Christian Langer and Florian Kuchenbauer
    Citation: Genome Medicine 2011 3:72
    Content type: Research highlight Published on:

  11. Initial high-throughput RNA sequencing (RNA-Seq) experiments have revealed a complex and dynamic transcriptome, but because it samples transcripts in proportion to their abundances, assessing the extent and na...

    Authors: Adam Roberts and Lior Pachter
    Citation: Genome Medicine 2011 3:74
    Content type: Research highlight Published on:

  12. A report on the Cold Spring Harbor Laboratory meeting on 'Personal Genomes', Cold Spring Harbor, New York, USA, 30 September to 2 October, 2011.

    Authors: Melissa Gymrek and Yaniv Erlich
    Citation: Genome Medicine 2011 3:73
    Content type: Meeting report Published on:

  13. A report on the Wellcome Trust Scientific Conference 'Epigenomics of Common Diseases', Hinxton, Cambridge, UK, September 13-16, 2011.

    Authors: Kate Revill and Benjamin Tycko
    Citation: Genome Medicine 2011 3:71
    Content type: Meeting report Published on:

  19. We present a new method to analyze cancer of unknown primary origin (CUP) samples. Our method achieves good results with classification accuracy (88% leave-one-out cross validation for primary tumors from 56 c...

    Authors: Kalle A Ojala, Sami K Kilpinen and Olli P Kallioniemi
    Citation: Genome Medicine 2011 3:63
    Content type: Method Published on:

  21. Pharmacogenetic testing holds major promise in allowing physicians to tailor therapy to patients based on genotype. However, there is little data on the impact of pharmacogenetic test results on patient and cl...

    Authors: Wendy Lorizio, Hope Rugo, Mary S Beattie, Simone Tchu, Teri Melese, Michelle Melisko, Alan HB Wu, H Jeffrey Lawrence, Michele Nikoloff and Elad Ziv
    Citation: Genome Medicine 2011 3:64
    Content type: Research Published on:

  24. Stem cells hold great promise for pancreatic beta cell replacement therapy for diabetes. In type 1 diabetes, beta cells are mostly destroyed, and in type 2 diabetes beta cell numbers are reduced by 40% to 60%....

    Authors: Gordon C Weir, Claudia Cavelti-Weder and Susan Bonner-Weir
    Citation: Genome Medicine 2011 3:61
    Content type: Review Published on:

  27. The hepatitis C virus (HCV) infects nearly 3% of the World's population, causing severe liver disease in many. Standard of care therapy is currently pegylated interferon alpha and ribavirin (PegIFN/R), which i...

    Authors: Katherine R Smith, Vijayaprakash Suppiah, Kate O'Connor, Thomas Berg, Martin Weltman, Maria Lorena Abate, Ulrich Spengler, Margaret Bassendine, Gail Matthews, William L Irving, Elizabeth Powell, Stephen Riordan, Golo Ahlenstiel, Graeme J Stewart, Melanie Bahlo, Jacob George…
    Citation: Genome Medicine 2011 3:57
    Content type: Research Published on:

  29. Hypoxia is a feature of most solid tumors and is associated with poor prognosis in several cancer types, including breast cancer. The master regulator of the hypoxic response is the Hypoxia-inducible factor 1α...

    Authors: Elena Favaro, Simon Lord, Adrian L Harris and Francesca M Buffa
    Citation: Genome Medicine 2011 3:55
    Content type: Review Published on:

  33. Q fever is a worldwide zoonosis caused by Coxiella burnetii. The disease most frequently manifests clinically as a self-limited febrile illness, as pneumonia (acute Q fever) or as a chronic illness that presents ...

    Authors: Malgorzata Kowalczewska, Zuzana Sekeyová and Didier Raoult
    Citation: Genome Medicine 2011 3:50
    Content type: Review Published on:

  34. Genetic risk models could potentially be useful in identifying high-risk groups for the prevention of complex diseases. We investigated the performance of this risk stratification strategy by examining epidemi...

    Authors: Raluca Mihaescu, Ramal Moonesinghe, Muin J Khoury and A Cecile JW Janssens
    Citation: Genome Medicine 2011 3:51
    Content type: Research Published on:

  37. Innovative 'systems' approaches to biomedical research offer substantial promise for advancing knowledge and improving health care, as outlined by Bousquet et al. in this issue. However, they are unlikely to impr...

    Authors: Wylie Burke and Susan Brown Trinidad
    Citation: Genome Medicine 2011 3:47
    Content type: Research highlight Published on:

  38. Data sharing is increasingly regarded as an ethical and scientific imperative that advances knowledge and thereby respects the contributions of the participants. Because of this and the ever-increasing amount ...

    Authors: Bartha Maria Knoppers, Jennifer R Harris, Anne Marie Tassé, Isabelle Budin-Ljøsne, Jane Kaye, Mylène Deschênes and Ma'n H Zawati
    Citation: Genome Medicine 2011 3:46
    Content type: Correspondence Published on:

  41. We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disor...

    Authors: Jean Bousquet, Josep M Anto, Peter J Sterk, Ian M Adcock, Kian Fan Chung, Josep Roca, Alvar Agusti, Chris Brightling, Anne Cambon-Thomsen, Alfredo Cesario, Sonia Abdelhak, Stylianos E Antonarakis, Antoine Avignon, Andrea Ballabio, Eugenio Baraldi, Alexander Baranov…
    Citation: Genome Medicine 2011 3:43
    Content type: Correspondence Published on:

  43. Genome-wide association studies have identified several genomic regions that are associated with breast cancer risk, but these provide an explanation for only a small fraction of familial breast cancer aggrega...

    Authors: Ying Huang, Dennis G Ballinger, James Y Dai, Ulrike Peters, David A Hinds, David R Cox, Erica Beilharz, Rowan T Chlebowski, Jacques E Rossouw, Anne McTiernan, Thomas Rohan and Ross L Prentice
    Citation: Genome Medicine 2011 3:42
    Content type: Research Published on:

    The Erratum to this article has been published in Genome Medicine 2012 4:19

  44. Embryonic stem cell specific microRNAs (miRNAs) have previously been shown to enhance the efficiency of transcription-factor-based reprogramming. However, whether reprogramming could be achieved entirely by mi...

    Authors: Tamer T Onder and George Q Daley
    Citation: Genome Medicine 2011 3:40
    Content type: Research highlight Published on:

  46. Achieving 'personalized medicine' requires enrolling representative cohorts into genetic studies, but patient self-selection may introduce bias. We sought to identify characteristics associated with genetic co...

    Authors: David E Lanfear, Philip G Jones, Sharon Cresci, Fengming Tang, Saif S Rathore and John A Spertus
    Citation: Genome Medicine 2011 3:39
    Content type: Research Published on:

  48. Human pluripotent cells such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) and their in vitro differentiation models hold great promise for regenerative medicine as they provide...

    Authors: Alvaro Rada-Iglesias and Joanna Wysocka
    Citation: Genome Medicine 2011 3:36
    Content type: Review Published on:
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Genome Medicine

ISSN: 1756-994X

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