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  1. Coronary heart disease (CHD) and stroke were key outcomes in the Women's Health Initiative (WHI) randomized trials of postmenopausal estrogen and estrogen plus progestin therapy. We recently reported a large n...

    Authors: Ross L Prentice, Sophie Paczesny, Aaron Aragaki, Lynn M Amon, Lin Chen, Sharon J Pitteri, Martin McIntosh, Pei Wang, Tina Buson Busald, Judith Hsia, Rebecca D Jackson, Jacques E Rossouw, JoAnn E Manson, Karen Johnson, Charles Eaton and Samir M Hanash

    Citation: Genome Medicine 2010 2:48

    Content type: Research

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  2. The ethical issues surrounding genotyping for single nucleotide polymorphisms (SNPs) or for copy number variation (CNV) are very different. SNP genotyping can focus on ancestry, risk probability, single gene d...

    Authors: Arthur L Beaudet

    Citation: Genome Medicine 2010 2:42

    Content type: Commentary

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  3. Myeloid leukemias are a heterogeneous group of diseases originating from bone marrow myeloid progenitor cells. Patients with myeloid leukemias can achieve long-term survival through targeted therapy, cure afte...

    Authors: Sigrun M Hjelle, Rakel B Forthun, Ingvild Haaland, Håkon Reikvam, Gry Sjøholt, Øystein Bruserud and Bjørn T Gjertsen

    Citation: Genome Medicine 2010 2:41

    Content type: Review

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  4. Panic disorder (PD) is the most common anxiety disorder. Although PD seems to occur unprovoked and the underlying etiology is not well understood, studies have consistently shown that genetic factors explain a...

    Authors: Johannes Schumacher and Jürgen Deckert

    Citation: Genome Medicine 2010 2:40

    Content type: Minireview

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  5. The biological causes of childhood obesity are complex. Environmental factors, such as massive marketing campaigns for food leading to over-nutrition and snacking and the decline in physical activity, have und...

    Authors: Hélène Choquet and David Meyre

    Citation: Genome Medicine 2010 2:36

    Content type: Review

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  6. Genome-wide maps of DNA regulatory elements and their interaction with transcription factors may form a framework for understanding regulatory circuits and gene expression control in human disease, but how the...

    Authors: Mun-Kit Choy, Mehregan Movassagh, Lee Siggens, Ana Vujic, Martin Goddard, Ana Sánchez, Neil Perkins, Nichola Figg, Martin Bennett, Jason Carroll and Roger Foo

    Citation: Genome Medicine 2010 2:37

    Content type: Research

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  7. Schizophrenia is a multifactorial complex disease with a large impact on society. Many hypotheses have been proposed over the years to explain its causes, and genomics and functional genomic approaches may she...

    Authors: Benedetta Frida Baldi, Christine Hoyer and Nicolas Le Novère

    Citation: Genome Medicine 2010 2:32

    Content type: Minireview

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  8. Patients are beginning to present to healthcare providers with the results of high-throughput individualized genotyping, and interpreting these results in the context of the explosive growth of literature link...

    Authors: Alexander A Morgan, Rong Chen and Atul J Butte

    Citation: Genome Medicine 2010 2:30

    Content type: Commentary

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  9. Young age at portoenterostomy has been linked to improved outcome in biliary atresia, but pre-existing biological factors may influence the rate of disease progression. In this study, we aimed to determine whe...

    Authors: Katie Moyer, Vivek Kaimal, Cristina Pacheco, Reena Mourya, Huan Xu, Pranavkumar Shivakumar, Ranajit Chakraborty, Marepalli Rao, John C Magee, Kevin Bove, Bruce J Aronow, Anil G Jegga and Jorge A Bezerra

    Citation: Genome Medicine 2010 2:33

    Content type: Research

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  10. Among the various sequence repeats that shape the human genome, trinucleotide repeats have attracted special interest as a result of their involvement in a class of human genetic disorders known as triplet rep...

    Authors: Piotr Kozlowski, Krzysztof Sobczak and Wlodzimierz J Krzyzosiak

    Citation: Genome Medicine 2010 2:29

    Content type: Minireview

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  11. Current policy statements discourage identification of disease carrier status in minors on the grounds that carrier information is of mainly reproductive significance. Such policies fail to consider that the c...

    Authors: Lainie Friedman Ross

    Citation: Genome Medicine 2010 2:25

    Content type: Commentary

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  12. As our knowledge of the complexity of gene architecture grows, and we increase our understanding of the subtleties of gene expression, the process of accurately describing disease-causing gene variants has bec...

    Authors: Raymond Dalgleish, Paul Flicek, Fiona Cunningham, Alex Astashyn, Raymond E Tully, Glenn Proctor, Yuan Chen, William M McLaren, Pontus Larsson, Brendan W Vaughan, Christophe Béroud, Glen Dobson, Heikki Lehväslaiho, Peter EM Taschner, Johan T den Dunnen, Andrew Devereau…

    Citation: Genome Medicine 2010 2:24

    Content type: Correspondence

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  13. Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by abnormalities in reciprocal social interactions and language development and/or usage, and by restricted interests and repetiti...

    Authors: Tewarit Sarachana, Rulun Zhou, Guang Chen, Husseini K Manji and Valerie W Hu

    Citation: Genome Medicine 2010 2:23

    Content type: Research

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  14. More than 300,000 children are newly infected with HIV each year, predominantly through mother-to-child transmission (HIV MTCT). Identification of host genetic traits associated with transmission may more clea...

    Authors: Bonnie R Joubert, Ethan M Lange, Nora Franceschini, Victor Mwapasa, Kari E North and Steven R Meshnick

    Citation: Genome Medicine 2010 2:17

    Content type: Research

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    The Erratum to this article has been published in Genome Medicine 2010 2:76

  15. How to efficiently integrate the daily practice of molecular biologists, geneticists, and clinicians with the emerging computational strategies from systems biology is still much of an open question.

    Authors: Roland Barriot, Jeroen Breckpot, Bernard Thienpont, Sylvain Brohée, Steven Van Vooren, Bert Coessens, Leon-Charles Tranchevent, Peter Van Loo, Marc Gewillig, Koenraad Devriendt and Yves Moreau

    Citation: Genome Medicine 2010 2:16

    Content type: Database

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  16. Antibiotic resistance is a public health issue of global dimensions with a significant impact on morbidity, mortality and healthcare-associated costs. The problem has recently been worsened by the steady incre...

    Authors: Gian Maria Rossolini and Maria Cristina Thaller

    Citation: Genome Medicine 2010 2:15

    Content type: Review

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  17. Continual discoveries on non-coding RNA (ncRNA) have changed the landscape of human genetics and molecular biology. Over the past ten years it has become clear that ncRNAs are involved in many physiological ce...

    Authors: Marco Galasso, Maria Elena Sana and Stefano Volinia

    Citation: Genome Medicine 2010 2:12

    Content type: Review

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  18. Evidence for genetic contribution to complex diseases is described by recurrence risks to relatives of diseased individuals. Genome-wide association studies allow a description of the genetics of the same dise...

    Authors: Naomi R Wray and Michael E Goddard

    Citation: Genome Medicine 2010 2:10

    Content type: Research

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  19. Skeletal muscle insulin resistance (IR) is considered a critical component of type II diabetes, yet to date IR has evaded characterization at the global gene expression level in humans. MicroRNAs (miRNAs) are ...

    Authors: Iain J Gallagher, Camilla Scheele, Pernille Keller, Anders R Nielsen, Judit Remenyi, Christian P Fischer, Karim Roder, John Babraj, Claes Wahlestedt, Gyorgy Hutvagner, Bente K Pedersen and James A Timmons

    Citation: Genome Medicine 2010 2:9

    Content type: Research

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  20. Ewing's sarcoma family tumors are a good example of how genome research has advanced our understanding of the molecular pathogenesis of an otherwise enigmatic disease. This group of embryonal bone tumors is ch...

    Authors: Heinrich Kovar

    Citation: Genome Medicine 2010 2:8

    Content type: Review

    Published on:

  21. Hepatitis C is a viral disease transmitted principally by blood, which affects millions of people worldwide. A significant proportion of those affected develop severe liver disease as a result. Only a fraction...

    Authors: David G Nathan and Stuart H Orkin

    Citation: Genome Medicine 2010 2:4

    Content type: Musings

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  22. Specific language impairment (SLI) is defined as an unexpected and persistent impairment in language ability despite adequate opportunity and intelligence and in the absence of any explanatory medical conditio...

    Authors: Dianne F Newbury, Simon E Fisher and Anthony P Monaco

    Citation: Genome Medicine 2010 2:6

    Content type: Review

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  23. Primary biliary cirrhosis (PBC) is an autoimmune hepatobiliary disease characterized by immune-mediated injury of small and medium-sized bile ducts, eventually leading to liver cirrhosis. Several studies have ...

    Authors: Carlo Selmi, Natalie J Torok, Andrea Affronti and M Eric Gershwin

    Citation: Genome Medicine 2010 2:5

    Content type: Review

    Published on:

  24. Genome-wide association studies have detected dozens of variants underlying complex diseases, although it is uncertain how often these discoveries will translate into clinically useful predictors. Here, to imp...

    Authors: Douglas M Ruderfer, Joshua Korn and Shaun M Purcell

    Citation: Genome Medicine 2010 2:2

    Content type: Method

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  25. Cancer cachexia is a multi-organ tissue wasting syndrome that contributes to morbidity and mortality in many cancer patients. Skeletal muscle loss represents an established key feature yet there is no molecula...

    Authors: Nathan A Stephens, Iain J Gallagher, Olav Rooyackers, Richard J Skipworth, Ben H Tan, Troels Marstrand, James A Ross, Denis C Guttridge, Lars Lundell, Kenneth C Fearon and James A Timmons

    Citation: Genome Medicine 2010 2:1

    Content type: Research

    Published on:

  26. Although statins are generally well tolerated, the most common adverse drug reaction from statin therapy is myopathy. This article reviews the current pharmacogenomic knowledge of statin-induced myopathy. Furt...

    Authors: Bas JM Peters, Olaf H Klungel, Frank L Visseren, Anthonius de Boer and Anke-Hilse Maitland-van der Zee

    Citation: Genome Medicine 2009 1:120

    Content type: Review

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  27. Public health preparedness requires effective surveillance of and rapid response to infectious disease outbreaks. Inclusion of research activities within the outbreak setting provides important opportunities t...

    Authors: Nicole F Dowling, Marta Gwinn and Alison Mawle

    Citation: Genome Medicine 2009 1:119

    Content type: Commentary

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  28. Women's Health Initiative randomized trials of postmenopausal hormone therapy reported intervention effects on several clinical outcomes, with some important differences between estrogen alone and estrogen plu...

    Authors: Sharon J Pitteri, Samir M Hanash, Aaron Aragaki, Lynn M Amon, Lin Chen, Tina Busald Buson, Sophie Paczesny, Hiroyuki Katayama, Hong Wang, Melissa M Johnson, Qing Zhang, Martin McIntosh, Pei Wang, Charles Kooperberg, Jacques E Rossouw, Rebecca D Jackson…

    Citation: Genome Medicine 2009 1:121

    Content type: Research

    Published on:

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